TGFb-induced Protein is Dysregulated in Osteoarthritis

TGFb is active, and correlates with activators of TGFb, following porcine coronary angioplasty

Objective: Restenosis following angioplasty involves processes that may be influenced by local production of cytokines. We investigated the expression of active and total transforming growth factor b (TGFb) following porcine coronary angioplasty (PTCA), and have correlated this with the expression of potential in vivo activators of TGFb: mannose-6-phosphate / insulin-like growth factor-II (M6P/...

Microenvironment and Immunology TGFb Is a Master Regulator of Radiation Therapy- Induced Antitumor Immunity

T cells directed to endogenous tumor antigens are powerful mediators of tumor regression. Recent immunotherapy advances have identified effective interventions to unleash tumor-specific T-cell activity in patients who naturally develop them. Eliciting T-cell responses to a patient's individual tumor remains a major challenge. Radiation therapy can induce immune responses to model antigens expre...

TRAF6 promotes TGFb-induced invasion and cell-cycle regulation via Lys63-linked polyubiquitination of Lys178 in TGFb type I receptor

TGFb Receptor Signaling Is Essential for Inflammation- Induced but Not b-Cell Workload–Induced b-Cell Proliferation

Protection and restoration of a functional b-cell mass are fundamental strategies for prevention and treatment of diabetes. Consequently, knowledge of signals that determine the functional b-cell mass is of immense clinical relevance. Transforming growth factor b (TGFb) superfamily signaling pathways play a critical role in development and tissue specification. Nevertheless, the role of these p...

Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension.

BACKGROUND Mutations in the bmpr2 gene, encoding the type II bone morphogenetic protein (BMP) receptor, have been identified in patients with pulmonary arterial hypertension (PAH), implicating BMP signaling in PAH. The aim of this study was to assess BMP signaling and its physiological effects in a monocrotaline (MCT) model of PAH. METHODS AND RESULTS Expression of BMP receptors Ib and II, an...